300 Despicable Deadpool #300 2018

Despicable Deadpool #300 concludes Gerry Duggan's acclaimed five-year run on the character. Seeking an end to his guilt-ridden existence, Deadpool ingests a bizarre alien bioweapon, causing widespread, violent vomiting among the Avengers and other heroes attempting to apprehend him. This triple-sized issue features a memorable, gross-out humor sequence and a meta appearance by writer Gerry Duggan himself, setting the stage for a new era for the Merc with a Mouth. It is a significant milestone for collectors.