Cable & Deadpool #15 2005

Cable & Deadpool #15 initiates the 'Enema of the State' storyline, finding Deadpool brainwashed by the enigmatic Black Box. Tasked as a mindless assassin, Deadpool predictably subverts his programming, embarking on a search for the vanished Cable. He enlists Siryn and Cannonball, utilizing Forge's technology to track Cable across various dimensions. This issue is notable for launching a significant arc that delves into Cable's ambitious plans and Deadpool's chaotic, yet crucial, involvement in their unfolding narrative.