Cable & Deadpool #43 2007

In Cable & Deadpool #43 from 2007, the story kicks off the two-part "Deadpool & Wolverine" arc. Wolverine is on a relentless hunt for HYDRA, who are behind recent terrorist activities. However, Deadpool finds himself protecting the new mastermind of HYDRA's operations, who turns out to be his friend Weasel. Cyclops enlists Deadpool to intervene and stop Wolverine's rampage before he inadvertently harms Weasel. The issue culminates in a confrontation where Wolverine brutally decapitates Deadpool, leaving the fate of Weasel and Bob uncertain. This issue is notable for its direct clash between Wolverine and Deadpool.