Deadpool #15 2009

Deadpool #15, from the acclaimed Joe Kelly run, sees Wade Wilson recovering after a battle with T-Ray. Landau, Luckman, and Lake enlist him to save the world from an escaped bio-weapon. A notable moment involves Deadpool's complicated relationship with Blind Al; after she forgives him for past torment, he offers her freedom, but she chooses to stay. This issue is a key part of the foundational series that shaped Deadpool's character and humor, making it significant to collectors.