Deadpool #3.1 2015

In Deadpool #3 from March 1997, Wade Wilson faces a critical flaw in his healing factor, unable to regrow a severed finger. Black Tom Cassidy taunts Deadpool by returning his previously lost hand's glove, prompting Deadpool to seek out his nemesis with Siryn. Instead, they encounter Doctor Killebrew, who reveals a shocking truth: Deadpool's healing factor is failing, and he is slowly dying. This issue is notable for collectors as it delves deeper into Deadpool's origins and the precarious nature of his powers, marking a significant early character development.