Deadpool #3 1997

Deadpool #3 from Marvel's 1997 ongoing series sees Wade Wilson's healing factor inexplicably failing, much to his embarrassment. After being taunted by Black Tom, Deadpool reluctantly teams with Siryn. Their pursuit leads them to Doctor Killebrew, one of Deadpool's creators, who reveals a grim truth: Deadpool's healing factor is malfunctioning because he is dying. This issue is notable for further exploring the intricacies of Deadpool's powers and his past connections to Weapon X, featuring key characters like Siryn, Doctor Killebrew, and T-Ray.