Deadpool #5 2013

Deadpool #5 from 1997 features Wade Wilson facing a critical breakdown of his healing factor. To survive, he believes he needs a transfusion of the Hulk's blood, leading to a direct confrontation with the green goliath. This early issue from the character's first ongoing series is notable for its exploration of Deadpool's unique physiology and his desperate, often humorous, measures to stay alive, further developing his chaotic persona and his relationship with Siryn.