Deadpool #66 2002

Deadpool #66, published in June 2002, kicks off a new storyline by Gail Simone and Udon Studios. In "Healing Factor: Chapter One, I Forget," Deadpool battles Rhino while suffering from a mental virus inflicted by the debuting Black Swan. Hired to retrieve Rhino's horn, Deadpool's impaired aim makes the fight challenging. He shrinks Rhino with Ant-Man's gas, ending the issue with a tiny Rhino in his care. This issue is notable for introducing Black Swan and starting a new creative era for the series.