Doctor Strange #19 2017

In Doctor Strange #19 (1976), Stephen Strange confronts Stygyro, who posed as Benjamin Franklin, and defeats him. Following this, Strange rejects the Ancient One's offer of oneness with the universe, resulting in him being stripped of his Sorcerer Supreme powers. This pivotal issue marks the first appearances of the enigmatic Xander and the powerful Creators, who begin to enact their plans to destroy the universe, setting the stage for future mystical conflicts.