In Spider-Man/Deadpool #13, the third part of the "Itsy Bitsy" arc, Spider-Man and Deadpool find themselves stranded in Weirdworld. Deadpool nurses an injured Spider-Man, who is grappling with a more aggressive demeanor since his return from the dead, a change that concerns Deadpool. The issue explores their evolving bond and features Deadpool's philosophical reflections on life. They battle strange creatures in Weirdworld, including the first appearances of several unique amalgamations like a Spider-Man/Deadpool hybrid. The story concludes with their return to New York, discovering Itsy Bitsy's devastating impact.