Spider-Man Deadpool #9 2016

Spider-Man/Deadpool #9 from Marvel Comics begins the "Itsy-Bitsy" story arc. Spider-Man and Deadpool are battling the Hateful Hexad when a new, formidable villain, Itsy-Bitsy, makes her shocking first appearance. She brutally dispatches the Hexad, leaving our heroes to face the blame and setting a dangerous new course for the duo. This issue is a key moment for collectors as it introduces a significant new character with ties to both protagonists, kicking off a major storyline.