Superman #422 1986

Superman #422, published by DC in August 1986, features the story "Dark Moon Rising!". Superman investigates mysterious werewolf murders, discovering a group of scientists from Lupus Labs experimented with radiated blood, creating lycanthropes. He battles these magical foes, ultimately aiding Thomas Lawrence, a scientist who became a werewolf but retained his conscience, to cure the afflicted. This Copper Age issue is notable for its classic Brian Bolland werewolf cover and as a pre-Crisis on Infinite Earths story.