Superman #49 1990

Superman #49 (DC, 1990) initiates the 'Krisis of the Krimson Kryptonite' storyline. In this notable issue, a dying Lex Luthor enlists Mr. Mxyzptlk to unleash Red Kryptonite, which strips Superman of his powers. This pivotal event leaves the Man of Steel vulnerable, leading to a brutal confrontation where Luthor physically bests a powerless Superman. It's a key moment for collectors, showcasing a rare instance of Superman's complete incapacitation and setting up a major challenge.