Venom #3 2011

In Venom #3 (2018), Eddie Brock loses control of the Venom symbiote, leading to a confrontation with Miles Morales, Spider-Man. The two eventually form an uneasy alliance to combat a monstrous Symbiote Dragon wreaking havoc across New York City. This issue is highly notable to collectors as it features the first full appearance of Knull, the ancient and powerful creator of the Symbiote race, significantly expanding the Venom lore.